Nehad Mahmoud Gumgumjee
King Abdulaziz University, KSA
Title: Synergistic antimicrobial effects and GC-MS analysis of phytocomponents of Commiphora quadricincta
Biography
Biography: Nehad Mahmoud Gumgumjee
Abstract
The Commiphora quadricincta, a small tree, belong to Burseraceae family is traditionally known for its medicinal properties. The present study was therefore carried out to investigate the synergistic antimicrobial activities and the phytochemicals of the bioactive components in the extract of this plant species. The antimicrobial activities of stem bark and leaves extract was investigated against 7 medically important bacterial strains, namely Bacillus subtilis, MRSA, Micrococcus, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aurues and Klebsella pneumoniae and five fungi (Aspergillus niger, A. fumigatus, A. flavus, Candida albicans and Saccharomyces spp.). The antibacterial activity was determined using agar well diffusion method. The most susceptible bacteria to this extract were Escherichia coli, while the most susceptible fungi were A. flavus. GC-MS analysis revealed that the ethanol extract of Commiphora quadricincta contained mainly; 2-Methyl-3-pentanol (2.84%); Butyl hydroxy toluene (22.32%); 9,12,15-Octadecatrienoic acid, 2-phenyl-1, 3-dioxan-5-yl ester (5.90); Ethyl isoallocholate (11.21%); à-Amyrin (2.22%) and Flavone 4-OH,5-OH,7-dioglucoside (11.21%). Most identified compounds are known to have antimicrobial activity.